Development of a new active ingredient from discovery to registration can take well over 10 years and cost more than $250 million dollars.  Thousands of compounds may be screened to eventually find one compound that will make it to market.  The initial screening of new active ingredients will narrow the field through a series of many different tests.  Many of these tests may be quite specific depending upon the targeted crop, pest and geography of the new active ingredient but they will typically focus on toxicology, metabolism, residues, ecotoxicology, physical-chemical properties, environmental impact as well as efficacy of the new active ingredient.  In this early stage of discovery, the new active ingredient will have many parameters defined including use rates, optimum formulation and also the registerability of the active ingredient in different parts of the world.  All of these studies are performed to ensure that the new active ingredient will be safe to the workers, environment, crops, food produced by limiting the non-target exposure.

Components of early product discovery and formulation in context of avoiding non-target exposure

ACS Fall 2020 Virtual Meeting

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