Access to industrial scale volumes of alkyl organophosphines, their derivatives, and phosphonium salts are critical to the successful commercialization of many applications including petrochemical catalysis, pharmaceutical, fragrance, fine chemical, polymer synthesis, etc.[1-3]. The industrial production and supply of these materials will be the focus of this presentation with some examples outlined in Scheme 1. These products (1-6) and similar derivatives, have found widespread application as precursors to ligands, and as ligands themselves with a wide range of chiral, mono- and multidentate structures now being commercially available. The underlying chemistry of phosphorus derivatization will be presented including the generation of phosphine gas and the synthesis of alkylphosphines. This includes atmospheric or high pressure chemistry with radical or acidic initiators as well as coupling chemistry and other synthetic methods. The discussion will provide insight into how various phosphorus starting materials such as phosphine gas (PH3) and white phosphorus (P4) and the chemistries employed can allow access to a diverse range of very versatile phosphorus-based materials in multi ton quantities and how product quality, which is critical to commercial consumers, can be handled.. Product applications to be highlighted include precursors for electronics applications, materials for coatings applications, ligands & catalysis as well as chemistries for thermoset material formulations. The presentation will also cover new product development and scale up facilities for this product line Two case studies will be presented outlining industrial production and characterization of phosphorus compounds and the relevant applications they support.

PH3: A versatile intermediate for large scale manufacture of organophosphines ligands and catalysts

ACS Fall 2020 Virtual Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.