Fenpicoxamid, a semi-synthetic derivative of the natural product UK-2A, has recently been developed for the control of wheat and banana diseases. It was found that derivatization of UK-2A allowed for relatively limited exploration of the key binding elements necessary for activity. As a part of a program around the identification of new broad spectrum fungicides, the total synthesis of a chiral-pool derived macrocyclic analog of UK-2A was completed. This presentation will detail the synthetic exploration around a new type of macrocyclic fungicides represented by CAS-507, and provide an overview of the general structure-activity trends observed.

Synthesis, biological activity and structure-activity relationships of a new broad spectrum fungicide

ACS Fall 2020 Virtual Meeting

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