Continuous Manufacturing (CM) offers many benefits over traditional fed batch bioreactor processes. The continuous perfusion of CM allows for increased culture productivity and an extended harvest period. However, CM cell culture runs can be significantly longer than traditional processes. The extended length of the process can prove challenging for completing Process Characterization (PC) studies efficiently. Understanding the steady-state of the process allowed us to greatly reduce the time needed to evaluate each condition. By implementing a creative PC design strategy that tests multiple conditions within the steady-state portion of a single bioreactor run, we were able to reduce the PC study timeline by &gt;60%.

Process Characterization Strategy for Upstream Continuous Manufacturing

ACS Fall 2020 Virtual Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.