We pursued an unconventional strategy of leveraging the ancient practice of traditional Indian medicine for discovering and developing Pharma and agrochemical candidates with high success rate, speed and cost-effectiveness. The starting point is a chemical series identified with a proven track record for efficacy and safety. Modern science including bioinformatics tools have been leveraged to identify novel chemotype(s) for lead optimization, for identification of mechanism of action as well as for establishing proof of concept in animal models.  We began our search based on clinical experiences, observations or available data on actual use in patients as a starting point. Since safety of the materials is already established, we undertook pharmaceutical development in parallel to controlled clinical studies. Drug discovery follows a ‘Reverse Pharmacology’ path from Clinics to Laboratories. We describe such approaches with selected synthesis methodologies implemented by us.

Development of a drug from conception to commercialization: a personal perspective

ACS Fall 2020 Virtual Meeting

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