Wearable sensors offer tremendous potential for biomedical applications. Sweat analysis is an attractive candidate that enables continuous and non-invasive molecular monitoring of circulating metabolites and nutrients. However, existing wearable sweat sensing platforms are primarily focused on a limited number of electrolytes and metabolites monitored via ion selective or enzymatic electrodes. Moreover, they either lack multimodal sensing functionality or require expensive micro/nanofabrication facilities. Here we report a mass-producible, all-laser-engraved graphene sensor that enables highly sensitive sweat analysis via differential pulse voltammetry and multiplexed vital sign monitoring. For the first time, we demonstrate here <i>in situ</i> continuous uric acid and tyrosine monitoring in human perspiration during exercise in both physically trained and untrained subjects. The use of this platform for non-invasive gout management is evaluated on clinically diagnosed gout patients and via a purine-rich meal challenge on healthy individuals. This flexible graphene sensor demonstrates great promise for non-invasive, personalized metabolic and nutritional management.

Highly sensitive laser-engraved graphene sensors for non-invasive monitoring of circulating metabolites and nutrients

ACS Fall 2020 Virtual Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.