Human gut microbiome plays crucial roles in harvesting energy from the diet, stimulating the proliferation of the intestinal epithelium, developing the immune system, and regulating fat storage in the host. Numerous diseases including type 1 & 2 diabetes (T1 & T2D), inflammatory bowel disease (IBD), gastric and colonic cancers, and even CNS-related disorders and aging have been shown to be linked to dysbiosis of gut microbial communities.<br/>Recent advances in microbiological analysis methods and application of systems biology in data interpretations allow us to understand the close association of the gut microbiota with human health and critical illnesses. And the human gut microbial information could be applied to prepare future disease prevention strategies, personalized health care guides, and novel therapeutic interventions. The composition of gut microbiome and its functions are affected by various intrinsic and extrinsic factors including host’s lifestyle, diet, ethnicity and geographic location, etc. However, the understanding of the gut microbiome of Asian population, whose lifestyle, dietary patterns, and genetic backgrounds differ from those of Western individuals, is still limited.

Population level association analysis of Korean gut microbiome with intrinsic and extrinsic host factors

ACS Fall 2020 Virtual Meeting

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