Inatreq<sup>TM</sup> active is Corteva Agriscience’s newest commercial antifungal compound for the control of <i>Septoria tritici</i> on wheat. Inatreq is a semi-synthetic active ingredient derived from the natural product UK-2A. Multiple metabolite and degradation studies were performed to support Inatreq registration. Over 45 metabolites and degradants were identified. One particular metabolite, M14, was the last to be confirmed structurally due to its size (MW632), the number of possible candidate structures and, ultimately, its relative instability. The total syntheses of three compounds proposed as M14, along with the analytical methods used for structural confirmation of this unstable degradant, will be presented.

In pursuit of Inatreq™ active’s unstable metabolite: M14

ACS Fall 2020 Virtual Meeting

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