Although cannabis products are legal for medicinal or recreational use in many US states and in Canada, there are currently no harmonized guidelines for pesticide residue tolerances.  Consequently, each state or nation with legalized cannabis has its own pesticide residue list with limits that may be quite different in each region. The AOAC has issued a Standard Method Performance Requirements document (SMPR 2018.011) that describes minimum recommended performance characteristics to be used to evaluate methods for determination of pesticides in cannabis.  AOAC has used the lowest tolerance level from any of the US states or Canada as the target action level for any proposed method with a recommended LOQ at 50% of the action level.  Although most of the target pesticides are amenable to LC-MS/MS analysis, many compounds have much lower detection limits using GC-MS/MS methods.  Therefore, both LC-MS (ESI and APCI) and GC-MS (EI and API) methodologies designed to meet AOAC requirements will be discussed.  <br/>

LC-MS/MS and GC-MS/MS to meet AOAC method performance requirements for multi-residue pesticide analysis in cannabis

ACS Fall 2020 Virtual Meeting

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