In recent years, a greater awareness of the environmental impacts of many chemical processes has created a push for greener chemical synthetic strategies. This is done in part through the development of minimal waste processes that maintain high atom economy and employ mild reaction conditions. Herein, a reaction that addresses this issue in the realm of cross-coupling reactions is described. A photoredox/Pd three-component reaction that combines a carboxylic acid, a carbonate, and an electrophilic olefin in a single synthetic step has been achieved. Through the use of a photoredox-facilitated decarboxylation process, a radical pathway can be accessed to achieve the two sequential C-C bond formations while releasing CO<sub>2</sub> as the only stoichiometric byproduct.

Photoredox/Pd dual-catalytic three-component cross-coupling

ACS Fall 2020 Virtual Meeting

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