Metabolism data is generated from crop studies performed according to the OECD 501 (Primary crop) and 502 (confined rotational crop) guidelines for the registration and re-registration of active ingredients. The crops selected are representative of one of five crop groups (root vegetables, leafy crops, fruits, pulses and oilseeds, and cereals), usually three crops are selected that are representative of the target use. The data generated is taken to be representative of other crops of the same nature, for example a leafy vegetable may be lettuce and this data would be read across for spinach. There is potential for the use of an active ingredient to change or to be used on additional crops after the initial registration. At this point there may be a data gap where the metabolism has not been investigated in two or more of the five crop groups and, as a result additional crop metabolism studies may need to be conducted in additional species, which can be costly and time consuming. Plant cell cultures have been shown to reliably produce metabolites that are representative of the whole organism, this presentation evaluates the feasibility of performing a crop species comparative metabolism study using in vitro cell cultures to generate data for the missing crop groups that may, potential fill the data gap.

Assessment of in vitro cell cultures as a comparative metabolism model to provide additional information for OECD 501 and 502 data read across

ACS Fall 2020 Virtual Meeting

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