Particles of any type, upon injection in vivo, adsorb serum proteins including antibodies that promote engulfment by macrophages, whereas nearby ‘Self’ cells are spared due to a 'marker of self' membrane protein that limits phagocytic clearance. We have studied this system in multiple biological and biophysical contexts, and made polypeptides for display on nanoparticles and viruses to inhibit engulfment. We have also applied the principles to engineer macrophages as 'living colloids' that attack and engulf cancer cells in immunocompromised mice. Repeated dosing with the engineered macrophages is safe and effective but necessary in part because of pathways related to how matrix elasticity directs cell fates. High affinity 'nano- Self' peptides are now being developed to block the macrophage checkpoint, and an immunocompetent mouse model commonly used for immunotherapy development is being scrutinized for safety, efficacy, and durable cures.

'Marker of Self' colloids:  From viruses and nanoscience to emerging medicines

ACS Fall 2020 Virtual Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.