It has become increasingly evident that microbial communities are responsible for a wide range of processes critical to human health and wellbeing. Diet is a key driver of microbial structure and function in the gut, outweighing even the host genotype. Thus, targeted dietary interventions are a promising avenue for modulation of the gut microbiome, rendering beneficial effects on host health and fitness. Microbes interact with each other and the host physiology via metabolites and other small molecules. Through use of advanced metabolomic analysis platforms, the complex interplay between the microbiota, host and diet can be characterized. This talk will describe the application of mass-spectrometry based metabolomics tools across multiple studies to understand the effects of dietary constituents, such as micronutrients, macronutrients and food additives, on microbiome function and host physiology. Through the combined use of advanced multi-dimensional analytical platforms and <i>in silico</i> computational library building approaches, we are investigating the immense chemical space of the human gut microbiome.<br/>

Leveraging metabolomics to investigate the chemical space of the human gut microbiome

ACS Fall 2020 Virtual Meeting

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