ACS Fall 2020 Virtual Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

American Chemical Society

Graduate Student & Postdoctoral Fellow Symposium

Construction of ultrastable protein nanoscaffolds for the assembly of spaceflight-compatible biosensors

O-GlcNAcylation of small heat shock proteins enhances their anti-amyloid chaperone activity

Allosteric activation of the mammalian nitric oxide receptor induces a distinct conformational rearrangement

Structural basis of alpha-synuclein toxicity identified by deep mutational scanning

Ester modification at the 3'-end of anti-microRNA oligonucleotides increases potency of microRNA inhibition

GNNQQNY as a dual cross-seeding peptide to promote amyloid fibrillation of both amyloid-β and hIAPP

Inhibition of NRAS signaling in melanoma through direct depalmitoylation using amphiphilic nucelophiles

Isolation, derivatization, α-glucosidase assay and docking studies of anti-diabetes metabolites from leaves of Chromolaena odorata (Siam weed)

Elucidating the biophysical and biological properties of the p3 peptide in Alzheimer’s disease

Advancing lysosomal targeting chimeras (LYTACs): Structural optimization and tissue specific protein degradation

Novel mechanism of ABC294640 (a selective sphingosine kinase-2 (SK2) inhibitor): Inhibition of mitochondrial complex I activity independent of SK2

Application of iridium complex for the visualization of cisplatin induced kidney injury in mice

Clickable methyltetrazine-indocarbocyanine lipids: a novel toolkit for efficient modifications of cell membranes

MYPT1 O-GlcNAcylation controls the sensitivity of fibroblasts to sphingosine-1-phosphate mediated cellular contraction

Dissecting the Med25-ATF6α protein-protein interaction using a lipopeptide natural product and its analogs

Discovery of an unnatural DNA modification derived from a natural secondary metabolite

Distinct ligand environment of iron-sulfur clusters fine-tunes the catalysis of radical SAM enzyme PqqE in PQQ biosynthesis

N-substituted oligopyrrolamide-mediated inhibition of Amyloid-β aggregation and associated cytotoxicity

ArnD is a deformylase involved in polymyxin resistance

Modulation of markers of cellular proliferation, growth and metastasis by Tridax procumbens in HepG2 cells

Antagonists pharmacologically chaperone opioid receptors

α-Effect nucleophiles as noncanonical substrates for microbial transglutaminase

Fundamental studies of the singlet oxygenation of melanin model compounds: Product, kinetics, and mechanistic studies

Hydrogen deuterium exchange within adenosine deaminase, a TIM barrel hydrolase, identifies networks for thermal activation of catalysis

Targeting C5a peptidase with an activity-based probe (ABP) to profile pathogenic streptococcus in complex communities

Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor

Activity-based protein profiling of the gut microbiome using clickable, photo-affinity xanthohumol based chemical probes

Chimeric small molecules inducing targeted protein phosphorylation by AMPK

Engineering an adaptable biosensor scaffold with monobody alternate frame folds

Recognition of histone H3 methylation states by the PHD1 domain of histone demethylase KDM5A

Dynamic and selective low-complexity domain interactions control gene transcription: A single-molecule study

DARPin-polymer conjugates prepared by enzymatic labeling and grafting-from polymerization for tumor-targeted imaging and drug delivery

Selection of an aptamer against thioflavin-T: Applications in DNA circuits to detect microRNAs

Chemical probes with programmable environmental release

Photoactivatable glycolipid probes for identifying mycolate-protein interactions in live mycobacteria

Metabolic labeling with an alkyne probe reveals similarities and differences in the prenylomes of  multiple brain-derived cell lines

Kinase chemical genetics in the closest living relatives of animals

Investigations of orientation effects in protein electron transfer chains

Engineering polysaccharide synthases toward size-controlled synthesis of heparosan oligosaccharide and expanding chemical space of heparan sulfate N-sulfo analogues

Unravelling how PaUbiX enzyme function at a molecular level

Towards personalized medicine: Photoacoustic imaging of glutathione enables companion diagnosis and targeted treatment of lung cancer

Next-generation protein-based fluorescent sensors

Discovery and characterization of retinoic acid derivatives as inhibitors of the Pseudomonas aeruginosa heme oxygenase

Local delivery of relaxin-2 as a novel treatment for shoulder arthrofibrosis

Deciphering the role of tandem BRD4 bromodomains using selective BRD4-D1 bromodomain inhibitors

Deep mutational scanning to explain the sequence fitness landscape of a four-helix bundle RNA-binding protein

Synthesis of Novel Small Molecule Inhibitors of Deubiquitinating Enzyme UCHL5 in the Proteasome

Development of EVA71 anti-viral compounds

Ribozyme mediated repair of damaged and mismatched RNA sequences

Molecular Design of a Protease Resistant Analogue of SDF-1α

Involvement of members of the aspartase/fumarase superfamily in the biosynthesis of coenzyme M

Profiling viral entry with metabolic engineering in SARS-CoV-2

Synthetic Collagen Heterotrimers by Conformational Design

Graduate Student & Postdoctoral Fellow Symposium

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Construction of ultrastable protein nanoscaffolds for the assembly of spaceflight-compatible biosensors