ACS Fall 2020 Virtual Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

American Chemical Society

New Reactions & Methodology

Functionalized (2,2,3,3-tetrafluorocyclobutyl)arenes – MedChem relevant building blocks

Sulfenate-anion-catalyzed diastereoselective synthesis of aziridines

Latent nucleophiles in lewis base catalysis

Synthesis and biological evaluation of 4-oxazolidinone antimicrobial agents

Halogenation of pyridines via heteroaryl phosphonium salts

Synthesis of highly enantioenriched sulfonimidamides by stereospecific SuFEx reaction of sulfonimidoyl fluorides with amines

Stereoisomerization of the human CAR activator CITCO complicates its use as a reference ligand

Redox-selective iron catalysis for α-amino C-H bond functionalization via aerobic oxidation

Iron-polypyridyl catalyzed C-H azidation of 3-acyl substituted indoles

Synthesis and binding of mannose-specific synthetic carbohydrate receptors

Hypophosphite and formate addition to alkenes under solvent-free and neutral aqueous conditions

Enantioselective synthesis of cyclopropanone equivalents and its application for the production of chiral β-lactams by formal [3+1] cycloaddition

Vicinal C-H functionalization of amines enabled by an interrupted Hoffman-Loffler-Freytag mechanism

Remote desaturation of amines by radical relay

Separation of cellulose/hemicellulose from lignocellulose in white pine sawdust using boron trihalide reagents

One pot synthesis of diversified 5-amine [1-H] tetrazole via Pd(0)/Fe(iii) dual catalyzed three component reaction as medicinally scaffolds

Modular approach to non-symmetric polycyclic aromatic hydrocarbons

Transition metal-free semireduction of propiolamide derivatives: Scope and mechanistic investigation

trans-hydroboration of propiolamides: Access to primary and secondary (E)-β-borylacrylamides

Overcoming back electron transfer facilitates the implementation of electron donor-acceptor complexes in catalysis

Novel photochemical-Pd-catalysed rearrangement sequences: Rapid access to the morphan ring system

Incorporation of heterocyclic aldehydes in Ugi-Smiles Diels-Alder reactions

Use of microwaves to synthesize propargylic ethers as precursors of 1,2,3-triazoles in click reactions

Nickel-catalyzed Suzuki–Miyaura couplings of amides: Scope and applications

Rapid NMR quantification of h-bonding ability of biologically active functional groups, drug fragments and organocatalysts

Development of radical-chaperone mediated functionalization of alcohols

Synthesis of STK076545: A reported protein disulfide isomerase inhibitor

Reactions of HDDA benzynes with C,N-Diarylimines

Reactivity of intermediates in borylative cyclization reactions

Mild and simple method for making MIDA boronates

Reactions of thermally generated benzynes with N–heterocycles: Pathway and product diversity

Green approch towards the synthesis of fluorosulfonyl 1,2,3-triazoles from bromovinylsulfonyl fluoride

Selectivity control of substituted triazol formation in microdroplets

Amine variation in Oxa-Michael Ugi-Smiles processes

Compared methods to synthesize 1,2,3-triazoles

Accelerated reactivity mechanism and interpretable machine learning model of N-sulfonylimines towards fast multicomponent reactions

General method to access sulfamides, sulfamates and sulfonamides from sulfur(VI) fluorides via calcium triflimide and DABCO activation

Employing circular dichroism for online reaction monitoring of enantiomeric excess

Imine-chaperone mediated ß C-H functionalization

Synthesis of halogenated ynamides and their application in cycloadditions

Synthesis of diverse spiro-α-prolines

Thorpe-Ingold effect versus electronic effects in Richman-Atkins cyclization

Cross-linked poly(4-vinylpyridine-N-oxide) as a polymer-supported oxygen atom transfer reagent

Synthesis of Functionalized Pyrrolines via Microwave-Promoted Iminyl Radical Cyclizations and Total Synthesis of (+)-Virosinine A.

Sequential photochemical and prins reactions for the selective synthesis of tricyclic scaffolds

One-pot pyridine alkylation via dearomatized pyridyl phosphonium ylides

Synthesis and structure investigation of methyl (Z)-2-(3-amino-2,2,4-tricyano-5-(2-methoxy-2-oxoethylidene)-1-methylcyclohex-3-en-1-yl) acetate obtained using one pot reaction

Piperazine bioisosteres for drug design

Advanced toolbox for PROTACs synthesis

Synthesis of a single chromophore for the development of photoluminescence switches: Detection of multiple analytes

Synthesis of sulfoximines and sulfonimidamides by highly chemoselective NH and O transfer

Synthesis of sulfonimidamides from sulfenamides via an unprecedented alkoxy-amino-l6-sulfanenitrile intermediate

On the use of differential scanning calorimetry for thermal hazard assessment of new chemistry: Avoiding explosive mistakes

Copper catalysed oxidative α-sulfonylation of branched aldehydes using the acid enhanced reactivity of manganese(IV) Oxide

Elevated reactivity of ten-membered bipyridyl strained alkyne

Synthesis of fluorinated tertiary amines via visible light-mediated carbonyl fluoroalkylative amination

Predictors of perfluoroalkyl and polyfluoroalkyl substance concentrations in the cord blood from a Chinese birth cohort

Disruptive chemistry: Innovations in bi-cyclic amine synthesis enabled by C-H bond functionalization

Regioselective nucleophilic substitution of the Baylis-Hillman (BH) Adducts: Applications to the synthesis of heterocyclic derivatives

Synthesis of β-lactams and cyclobutanones via formal [3+1] cycloaddition of chiral cyclopropanone equivalents

General synthesis of cyclopropanols via organometallic additions to readily accesible cyclopropanone precursors

Assessment of the bioorthogonality of the pleiotropic nitrile imine 1,3-dipole

Palladium catalyzed cascade cross coupling and making polyaromatic ethers

Homoconjugation enhances luminescence and reverse intersystem crossing in thermally activated delayed fluorescent triptycenes

Benzothiazolium Salts: Versatile reagents to prepare fluorine-containing organic molecules

Development of new methods to synthesize heterocyclic compounds (Quinolines, Oxazolines and Imidazolines)

Photo-NHC Catalysis: Ketone photochemistry with carboxylic acid drivatives

Chemical synthesis and structural characterization of hydroxysterols

Novel radical chlorodifluoromethylation methodology and Its application on an oncology candidate

Iodonium salts as group transfer reagents – N-heterocyclic carbene-catalyzed synthesis of vinyl and propargyl ketones

Single electron transfer strategy using iron-polypyridyl complexes in cycloaddition reactions

Total synthesis of bioactive natural products isolated from marine sponges

NMR quantification of halogen-bonding ability to evaluate catalyst activity

Borylative heterocyclization: controllable and easy access to borylated heterocycles

Self-condensing ring-opening metathesis polymerization: A novel approach to hyperbranched polymers

DNA (inter)actions controlled by light

Synthesis of libraries of polymers from half-esters obtained by practical selective monohydrolysis reactions of symmetric diesters

Merging enamine catalysis with hard metal Lewis acid catalysis for asymmetric organic transformation

Synthesis of pyrroloindolines through formal [3+2]-cycloaddition of indoles with chiral N-2-acetamidoacrylyl oxazolidinones

Synthesis of 2,4’-bipyridines via a unique radical coupling of cyanopyridines and heteroaryl phosphonium salts

Oxalyl chloride as a convenient donor of one and two carbonyl groups in chemical transformations

Photocatalytic synthesis of heterocyclic compounds through a cationic enol radical from ynamide and pyridine N-oxide

Diversity-oriented asymmetric synthesis of highly substituted tetrahydroquinoline

Oxazoles from alcohols and nitriles via tandem hydrogen atom transfer

New reactions of aliphatic trifluoromethyl- tetrafluoro-λ6-sulfanyl (CF3SF4) containing allyl esters and acids

Synthesis of sultams from vinyl aziridines and 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide)

Strategies toward saturated cyclic-amine diversification

Vanadium-catalyzed intramolecular coupling of tethered phenols: Formation of phenol-dienone products

Accelerated energetic syntheses through the use of confined volume systems generated by ambient ionization sources

Re2O7 - mediated dehydrative cyclizations: Method towards 2,6- trans dihydropyran synthesis

Etherification between vinyl ether carbanions and electrophilic peroxides as a route to ketene acetal synthesis

Cross metathesis labeling with fluorescent probes for the identification and quantitation of unsaturated lipids

Aluminum amalgam reduction of arylnitro groups

New Reactions & Methodology

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Functionalized (2,2,3,3-tetrafluorocyclobutyl)arenes – MedChem relevant building blocks