A synthetic approach for the accelerated assembly of quinoline-4-carboxamide and quinoline-4-carboxylate nuclei is presented. The methodology is based on the rearrangement of N-vinylisatins promoted by different types of amines (or ethanol) in a Pfitzinger-type mechanism that in turn builds the quinoline ring system. The reaction took place only by heating the starting materials in ethanol, without any additive.

Expedited Assembly of Quinoline-4-Carboxamides and Quinoline-4-Carboxilates Through the Rearrangement Of N-Vinylisatins.

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