Alzheimer's disease is one of the pathologies that causes the most damage in the adult group, arising the need for more efficient drugs with less side effects. It demands the design of multitarget drugs against AD.  In the present work, a computational study of five targets involved in Alzheimer's disease: AChE, BChE, BACE1, GSK-3 and CB2 is performed. Binding sites of these five targets will be characterized and analyzed with the aim to find a receptophore between them, as a starting point in multi-target drug design for AD.

Targeting Alzheimer's disease through computational polypharmacology

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