Human Immunodeficiency Virus (HIV) can cause Acquired Immunodeficiency Syndrome (AIDS), a disease that has become a worldwide pandemic. The situation in sub-Saharan Africa is particularly bad, with 67% of the world's HIV infections occurring there in 2007.  HIV can be transmitted to babies from their infected mothers through breast milk.  Nevirapine is a relatively inexpensive drug that is effective in preventing HIV transmission through breast milk.  However, in sub-Saharan Africa , access to medications such as nevirapine can be very limited.  Our goal is to develop a sustained-release delivery system for nevirapine, which would give many additional people access to the drug.  Nevirapine crystals of the appropriate size were prepared and coated with polylactic acid using a fluidized bed coater.  The half-life of the particles in vitro and in vivo were measured.

Development of a sustained-release delivery system for the anti-HIV drug nevirapine

239th National Meeting (2010)

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