Ethanolic extract from the roots of L. radula were investigated, thecompounds were evalutate for cytotoxicity according to promega cell Titer blueviability assay kit. Briefly, the ethanolic extract were dissolved in water andpartitioned with hexane, CHCl2 and AcOEt. The aqueous phase was subjected to MPLC over HP-20SS resin at 70 psi pressure using a step-gradient of MeOH-H2O mixtures (100% H2O to 100% MeOH). The MPLC fraction eluting with 1:1 MeOH-H2Owas further separated by gradient. Five known phenylpropanoids (samioside,arenarioside, calceolarioside E, verbascoside, and isonuomioside A) were isolated and as well as a new phenylethanoids tetraglycoside (1) and lignan (2)  were elucidated by means of spectroscopy methods: NMR Varian Inova (600 and 800 MHz instruments) and VNMRS (400 and 500 MHz instruments) ESIMS data were acquired on a LCT Premier (Waters Corp.). All the compounds did not inhibit cell viability at 10�M against several cell lines. 

Raduloside and radulolignin: A new phenylethanoid tetraglycoside and lignan from polar roots extract of <i>Lantana radula</i>

239th National Meeting (2010)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Raduloside and radulolignin: A new phenylethanoid tetraglycoside and lignan from polar roots extract of Lantana radula