A simple combination of metal-catalysis and organocatalysis allows for a highly chemo- and enantioselective dynamic kinetic asymmetric transformation (DYKAT) between enals and propargylated carbon acids to give functionalized cyclopentenes with 91-99% ee. The reaction is the first example of a DYKAT that proceeds by combination of iminium, enamine and transition metal cascade catalysis and can give access to an all-carbon quaternary stereocenter.

Dynamic kinetic asymmetric transformation (DYKAT) by combination of amine and transition metal cascade catalysis

239th National Meeting (2010)

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