The bromotyrosine alkaloids, suberedamines A and B, isolated from the Okinawan marine sponge Suberea species were found to possess cytotoxic properties with promising benefits for treatment of diseases. Since suberedamines A and B are difficult to obtain in substantial amounts naturally, a plausible synthesis of suberedamines A and B was discovered from studying the structure of suberedamines A and B. Leading to the possibility that suberedamines A and B can be synthesized by coupling a tyrosine derivative (1) and a tyramine derivative (2). The poster presentation will discuss the progress of the total synthesis of suberedamine A.

Progress toward the total synthesis of suberedamine A

239th National Meeting (2010)

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