Chiral oxidation reaction is a crucial chemical transformation in the chemistry and pharmaceutical industries. Particularly, the asymmetric epoxidation of a,�-unsaturated carbonyl compounds is very important reaction because of the usefulness of the corresponding a,�-epoxy carbonyl compounds. The a,�-epoxy ketone could play a important roll as initial step for further reaction to provide �-hydroxyl ketones for prostaglandins and a-hydroxy ketones which can be used as biologically active antitumor agents and drugs. Recently, catalysis via biomolecules received growing interest due to propensity to catalyze the functionalization of C-H and C-C bonds.  In addition, complexes of transition metals and amino acid are at the core of numerous biological transformations such as hydrogenation, oxidation, polymerization and so on.  It is also well known that enzymatic biological transformation would give high yield and selectivity. However, it required long process to produce the catalyst and even difficult to handle the reaction system in the laboratory. In this regards, we would like to bring such biological important transformations to be a simple catalytic process using simple but efficient catalyst system. In here, particularly, we introduce immobilized amino acid onto direct synthesis amino functionalized mesoporous silica for this particular purpose. Besides offering efficient catalytic performance, this catalyst system also offers recyclability, easy handling and easy preparation.

Chiral oxidation reaction over single-site heterogenized biomimetic amino acid complexes catalyst

239th National Meeting (2010)

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