Efficient borylation of protected L-tyrosine triflate with pinacolborane was achieved despite previous reports to the contrary. In addition to the use of an inexpensive boron source, the reaction was carried out in the presence of only 0.5 mol% palladium catalyst. This represents a practical entry to 4-borono-L-phenylalanine (L-BPA) derivatives.

Palladium-catalyzed borylation of L-tyrosine triflate derivatives with pinacolborane: Practical route to 4-borono-L-phenylalanine (L-BPA) derivatives

239th National Meeting (2010)

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