A new method for the chemical synthesis oflanost-8-en-3�-ol-7,11-dione, and inhibitor of HMG-CoA reductase hasbeen developed. The new approach to computer-aided informatics has been investigated. The allylic oxidation of ?8-steroids was initially accomplished by chromic acid mixture with limited success. Amines complexed with chromium VI reagents have provided new routes to allylic oxidation. PCC (pyridinium chlorochromate) under different reaction conditions, is an effective reagent in augmenting the allylic oxidation of  ?8-steroids. We have found that lanost-8-en-3�-ol-7,11-dione is a significant inhibitor of HMG-CoA reductase. A 1.26 �M concentration of sterol was required for a 50% inhibition of enzyme activity.

Chemical synthesis and informatics of lanost-8-en-3β-ol-7,11-dione: An inhibitor of HMG-CoA reductase

239th National Meeting (2010)

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