The transition metal-catalyzed allylic amination reaction provides a powerful method for the asymmetric synthesis of C-N bonds present in biologically active natural and unnatural products.  We have recently demonstrated the synthetic utility of aza-ylides in the stereospecific rhodium-catalyzed allylic amination reaction. This poster will outline the ability to tune the aza-ylide pronucleophile to facilitate the stereospecific and enantioselective metal-catalyzed allylic amination.

Asymmetric metal-catalyzed allylic amination reactions

239th National Meeting (2010)

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