Development of fully synthetic carbohydrate-based vaccines becomes a promising and exciting new research focus. Recently, considerable efforts have been directed toward design, synthesis and clinical evaluation of carbohydrate-based vaccines against microbial pathogens and cancers. Organic synthesis has clearly emerged as a key force in providing sufficient, pure, and structurally well-defined natural/unnatural carbohydrates for research and biomedical applications. Herein, we demonstrate our efforts in developing a simple, facile, and cost-effective glycosylation method for rapid access to biologically important carbohydrate antigens. We will also demonstrate the application of this new glycosylation method in the synthesis of the saponin immune adjuvant, another important component of our multi-component fully synthetic carbohydrate-based vaccine design.

Effort towards the development of synthetic
carbohydrate-based vaccine

239th National Meeting (2010)

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Effort towards the development of synthetic carbohydrate-based vaccine