Carbohydrates are important biological substances whose microbiological and physiological activities depend largely on their redox behavior . The study of carbohydrates is one of the most exciting fields of organic chemistry. Vast literature is available on the kinetics of oxidation of carbohydrates by various organic and inorganic oxidants.D-Glu is a monosaccharide with wide synthetic applications and plays an active role in biological system.  Oxidation of D-Glu is of great importance both from chemical and biological point of view. Considering its importance for life on earth, the reaction involving carbohydrates are of considerable interest . Kinetics of oxidation of D-glucose (D-Glu) by N-bromopthalimide (NBP) in presence of chloro complex of Ru(III) as a homogenous catalyst in perchloric acid medium has been investigated. The kinetic results indicate that the reaction was first order on [NBP] and zero order on [D-Glu]. The reaction followed first-order kinetics with respect to Ru(III) chloride in its lower concentration range and tends to zero-order at its higher concentration. Negative effect of [H+] and [Cl-] ion on the rate of oxidation were observed whereas change of ionic strength (�) of the medium had no affect on the oxidation velocity. The values of rate constants observed at five different temperatures were utilized to calculate the activation parameters. Formic acid and Arabinonic acid have been identified as the main oxidation products of the reaction. A plausible mechanism from the results of kinetic studies, reaction stoichiometry, and product analysis has been proposed.

Kinetic study of oxidation of  Glucose by N-bromophthalimide in the presence of ruthenium(III)chloride

239th National Meeting (2010)

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