Recent progress in our quest to develop structurally simple and air-stable P,N-ligands that enable the palladium-catalyzed cross-coupling of aryl and heteroaryl chlorides to diverse range of amine and related substrates, including primary alkyl- and arylamines, secondary amines, N-H imines, hydrazones, lithium amide, and ammonia will be disclosed. In most cases, the reactions can be performed at low catalysts loadings (0.5 � 0.02 mol % Pd) with excellent functional group tolerance and chemoselectivity. Preliminary results of coordination chemistry and stoichiometric reactivity studies that seek to provide insight into the behavior of such P,N-ligands in this chemistry will also be presented.

New P,N-ligands for use in supporting versatile catalysts for the cross-coupling of aryl chlorides and amines

239th National Meeting (2010)

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