Positron emission tomography (PET) is a powerful noninvasive technique for investigating physiological parameters (blood-flow, glucose metabolism,receptor binding, and drug metabolism). It is known that agents whichinhibit binding between heparin sulfate proteoglycan and the amyloid precursorare effective anti-amyloid compounds both in vitro and in vivo.2-Acetamido-2,4-dideoxy-D-glucosamine analogs have shown amyloid inhibitoryproperties in vivo. Accordingly, we designed and synthesized two novel radiolabeledfluorinated analogs of 2,4-dideoxy-D-glucosamine. We wish to report the synthesis of 2-acetamido-2,4-dideoxy-4-[18F]fluoro-D-hexapyranoses, 1 and 2,  using microfluidic techniques  

Synthesis of 2-Acetamido-2,4-dideoxy-4-[<sup>18</sup>F]fluoro-D-hexopyranoses

239th National Meeting (2010)

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Synthesis of 2-Acetamido-2,4-dideoxy-4-[18F]fluoro-D-hexopyranoses

Synthesis of 2-Acetamido-2,4-dideoxy-4-[¹⁸F]fluoro-D-hexopyranoses