Notable alterations in energy metabolism have been linked to many vital cellular processes and harmful diseases. Comprehensive understanding of the perturbations of energy metabolism and invention of novel biochemical tools for its investigation are of significant current interest. Our laboratory is developing a series of new small-molecule modulators of energy production pathways. We will present our studies on highly potent natural product-based suppressors of mitochondrial function and a new class of glycolytic inhibitors identified by high-throughput screening of our small-molecule libraries.

Small-molecule modulation of energy metabolism

239th National Meeting (2010)

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