An efficient method for copper-catalyzed sp2 C-H bond deprotonative  functionalization has been developed. Acidic C-H bonds of electron-rich and electron-poor heterocycles as well as arenes possessing at least two electron-withdrawing groups can be directly functionalized by employing copper catalyst in combination with suitable bases. Good functional group tolerance and high positional functionalization selectivity has been observed.

Copper-catalyzed arene functionalization

239th National Meeting (2010)

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