Novel analogs of GW4064 varying the isoxazole ring were synthesized and evaluated as modulators of the farnesoid X receptor (FXR). Several novel ring replacements were discovered exhibiting good potency. The most interesting analogs include pyrazole- and oxazolone-containing moieties with varying lengths to the substituted aromatic ring. 

Novel isoxazole analogs of GW4064 as farnesoid X receptor agonists

239th National Meeting (2010)

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