Recently, the philosophy of 'click' chemistry and robust, efficient, and orthogonal reactions have triggered applications of soft materials in a wide variety of disciplines spanning from biology, engineering, and physics, among others. Within the set of click transformations, the copper-catalyzed Huisgen cycloaddition reaction has received much attention due to its orthogonal nature. More recently, the coupling reaction between thiols and alkenes (thiol-ene) is rapidly gaining momentum due to its short reaction timescales, insensitivity to oxygen inhibition, ability to proceed with or without solvent, orthogonality, and high degrees of efficiency. By taking advantage of thiol-ene click chemistry, we have developed a set of compounds that are chemoselective, orthogonal, and display outstanding characteristics to be employed in various disciplines involving functional systems of well-defined chemical structure and composition.  The talk will highlight our current results from the projects employing thiol-ene chemistry for the development of functional materials.

Click chemistry strategies for the fabrication of dendrimers

239th National Meeting (2010)

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