Amphiphilic supramolecular assemblies, such as liposomes, micelles, and dendrimers, exhibit a great potential in applications such as drug delivery and sensing, because of their ability to sequester hydrophobic guest molecules in the aqueous phase.  In addition to sequestering guest molecules, it is also essential that these sequestered guest molecules are released in response to a specific stimulus.  While such a work in the past has focused on secondary biological stimuli such as pH, temperature, and redox conditions, there has been very limited work on systems that respond to the primary stimulus, protein concentration.  In this talk, we will outline our strategies on nanoscale supramolecular assemblies that respond to the primary biological stimulus and their potential utility in both sensing and drug delivery.

Protein-responsive supramolecular assembly and disassembly

239th National Meeting (2010)

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