Over one third of the world's population is infected with tuberculosis and it is second only to AIDS as a leading cause of death from infectious diseases.  In 1993, the World Health Organization declared a global health emergency with the resurgence of tuberculosis in the setting of HIV infection and with the emergence of multi-drug resistant TB.  In 2004, 14.6 million people had active TB, 8.9 million new cases were documented, and 1.7 million deaths were attributed to TB (2), making it the second leading cause of death after HIV from an infectious disease.  We have identified small molecules that modulate different TB physiologic states including replicating and non-replicating states and intracellular bacteria within infected macrophages and are using these small molecules as probes to better understand the complex biology of TB and establish new paradigms for how one might intervene on this disease.

Chemical biological approach to TB

239th National Meeting (2010)

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