Affinisine oxindole has been isolated from the leaf extract of Alstonia angustifolia var. latifolia. Oxindole alkaloids are an important group of monoterpene alkaloids which contain the oxindole moiety often associated with significant biological activity. The spiro(indole-pyrrolidine) ring system is a frequently encountered structural motif in many pharmacologically relevant natural products. Progress towards the total synthesis of this alkaloid will be presented.

Progress towards the total synthesis of affinisine oxindole

239th National Meeting (2010)

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