Our ongoing interests in copper/dioxygen and heme/copper/dioxygen bioinorganic chemistry have led us to probe new chemistries that include nitrogen monoxide (�NO), a radical diatomic molecule with a history in transition metal chemistry and importance in biology and metallo-enzymology. Here, we describe nitrogen monoxide reductive coupling chemistry mimicking aspects of known biological chemistry involving heme-copper oxidases such as cytochrome c oxidase.  Heme-copper assemblies can also produce nitrogen monoxide via nitrite reduction chemistry and that chemistry will be discussed.  We also demonstrate the likely generation of a peroxynitrite-heme moiety (O=N-O-O�; normally described as the product of superoxide anion plus �NO) derived from a heme-dioxygen adduct which reacts with nitrogen monoxide to give a heme-nitrate final product.

New heme-copper and heme nitrogen monoxide, nitrite, and dioxygen chemistry

239th National Meeting (2010)

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