Due to increased intake of refined high calorie foods globally we are facing disorders of carbohydrate metabolism leading to chronic health problems such as obesity and associated type 2 diabetes. Important therapeutic approaches available for managing early stages of type 2 diabetes is by controlling the absorption of glucose through the reduction of starch hydrolysis by inhibiting pancreatic alpha-amylase and limiting the absorption of glucose by inhibiting intestinal alpha-glucosidase enzymes. Natural alpha-amylase and alpha-glucosidase inhibitors from plant foods offer a good strategy to control the post-prandial hyperglycemia and provide benefits without the side effects. Further these plant foods have bioactive profiles that have potential to manage the macrovascular complications such as blood pressure through inhibition of Angiotensin I-Converting Enzyme (ACE) and micro vascular complications through antioxidant activity. These biochemical strategies provide the rationale basis for animal and clinical studies to design effective dietary therapies for managing for type 2 diabetes.

Phenolic antioxidant-enriched plant foods for prevention and management of type 2 diabetes and its complications

240th National Meeting (2010)

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