Our group has a long-standing interest in the total synthesis of complex alkaloids and in particular in the construction of oroidin-derived metabolites. This poster will describe a concise route for the enantioselective total synthesis of cyclooroidin and the synthesis of the northern fragment of nagelamide R. A concise entry into the all trans-substituted spiro cyclopentyl imidazolone system found in palau'amine and related natural products will also be described. This approach employs an IMDA reaction of an enyne followed by an oxidative rearrangement. 

Total synthesis of cyclooroidin and studies towards some oroidin dimers

240th National Meeting (2010)

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