Organic scaffolds, peptides, and oligomers continue to play an important role for understanding how the positioning of chemical functionalities in space control chemical reactivity. This work describes a new class of organic scaffolding called Bis-Peptides that position multiple functional groups rigidly in 3-dimensional space and have shown promise for applications in catalysis and molecular recognition.  Bis-Peptides also possess solubility in a broad range of solvents, including water.  To investigate electron transfer reactions in water and compare them to the corresponding reactions in organic solvents, water-soluble Bis-Peptide oligomers were designed with pyrene (electron acceptor) and dimethylaniline (electron donor) moieties of varying distances and orientation. The study of these donor-bridge-acceptor constructs is elucidating new features of water's role in electron transfer reactions.

Bis-Peptide scaffolds as designed probes for electron transfer phenomena

240th National Meeting (2010)

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