A water-soluble derivative of the chemotherapeutic agent taxol was synthesized with bioconjugation functionality and attached to the interior surface of empty capsids of bacteriophage MS2 at over 70% yield. The modified capsids retained their form upon taxol attachment, as well as after extended incubation in cell culture media.  When incubated with MCF-7 cells, the capsids released taxol, and the resulting cell viability levels were similar to those observed upon treatment with free taxol in solution. Various active targeting functionalities have been explored for attachment to the exterior surface of the capsid, and several other compounds of low water solubility have been similarly derivatized for bioconjugaton purposes.

Genome-free viral capsids as multivalent carriers for taxol delivery

240th National Meeting (2010)

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