Bisphosphonates are well known for their affinity to bone tissue, were they inhibit osteoclast activity. They are often the drug of choice in the treatment of bone resorption diseases, such as osteoporosis, Paget's disease, and other conditions that feature bone fragility while encouraging osteoclasts to undergo apoptosis. The synthesis of the corresponding bisphosphonate derivative of �-alanine (an endogenous �-amino acid) using tris(trimethylsilyl) phosphite (TMSP) under different conditions is described. The product is characterized spectroscopically.

Reactivity of tris(trimethylsilyl)phosphite: Synthesis of bisphosphonate derivatives of β-alanine

240th National Meeting (2010)

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