This presentation introduces a new class of macrocyclic �-sheet peptides that tolerate a variety of amino acid sequences and are water-soluble and non-aggregating. The macrocyclic �-sheets accommodate sequences from various amyloidogenic peptides and comprise 54-membered rings containing natural amino acids and unnatural turn and template units. We have preparedmacrocyclic �-sheets containing sequences from amyloid �-peptide, tau protein, yeast Sup35 prion protein, and human prion protein. We are using these amyloid �-sheet mimics to study and inhibit amyloidogenic peptide aggregation. 

Mimicry of amyloid β-sheets

240th National Meeting (2010)

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