Mechanistic studies in cell culture describe the impact of specific nutrients and phytochemicals on antioxidant pathways.  Translating studies to the whole animal permits studies that are prolonged and that compare bioactivity of individual compounds with that of the whole foods from which they are derived.  Like many vegetables, crucifers are a rich source of antioxidant vitamins and polyphenols; they also accumulate selenium, important for glutathione peroxidase.  In addition, crucifers are renowned for their content of glucosinolate-derived isothiocyanates, able to upregulate glutathione and thioredoxin synthesis, potentially altering redox within the body.Supported by USDA/NIFA 2009-02961

Relating in vitro research on the antioxidant impact of crucifer components to dietary redox regulation

240th National Meeting (2010)

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