Absorption of visible light by cellular components can giverise to both background fluorescence and phototoxicity. Living tissue is most transparent to light beyondthe visible region, in the near-infrared (650-900 nm). Oxazine dyes are compactnear-IR fluorophores that are cell-permeable and highly photostable. Here wedescribe our work on the synthesis and application of these molecules for thelabeling of intracellular proteins and the creation of fluorescent sensors ofthe intracellular environment.

Near-IR oxazine fluorophores for live cell imaging

240th National Meeting (2010)

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