Colloid nanoparticles such as noble metalnanocrystals and quantum dots have been widely used in biological detection andimaging. The coating on nanocrystals played a critical role on their colloidalstability and functionalization towards biological applications. By mimickingthe Nature's way to coat heavy metal nanoclusters, we have preparednanoparticles coated with various natural ligands such as amino acids, peptidesand proteins. For example, highly fluorescent glutathione-coated quantum dotsand BSA-coated Au nanoclusters had been synthesized in aqueous solution. Withnatural biopolymer coatings, these nanoparticles achieved excellent colloidalstability at physiological condition, and could be easily conjugated with smallbioprobes for various applications.

Bio-inspired synthesis and coating of nanoparticles for biological applications

240th National Meeting (2010)

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