We have developed a novel polymerhydrogel capable of actively inducing the coagulation cascade, via the potentactivation of Factor VII (FVII), leading to the formation of a robust hemostatic clot.  Citrated plasma experiments were initiallyused to investigate the ability of specific hydrogel compositions to inducefibrin formation, and determine a composition capable of inducing optimized ormaximum fibrin formation.  Successiveinvestigation into the biological mechanism of the process confirmed theability of the optimized hydrogel to potently induce the activation of FVII.Dynamic mechanical analysis was used to explore the relationship between the mechanicalrigidity of the hydrogel and its ability to induce coagulation.  Animal experiments confirmed the ability ofsuch a polymer hydrogel to provide rapid and effective hemostasis in vivo.  Future experiments will be aimed at conductingclinical diagnostic experiments in fresh, human blood along with more advancedin vivo animal trials to further optimize the material for trauma and surgical application.

Coagulation-inducing polymer hydrogel for hemostatic application

240th National Meeting (2010)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.