Reactive oxygen species (ROS) are implicated in several cancers and neurodegenerative diseases.  Our research focuses on covalent modification of silica nanoparticles with TEMPO, a stabilized nitroxyl radical, which functions as an ROS scavenger.  Presented here are our current linker and payload release strategies. To validate possible therapeutic efficacy, macrophage uptake and superoxide scavenging abilities of the functionalized particles were assessed.

Synthesis and biological evaluation of nitroxide-functionalized silica nanoparticles

240th National Meeting (2010)

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