The photolabile carbon-cobalt bond of alkylcobalt(III)salen complexes is stable to aqueoushydrolysis but is easily cleaved with red light making these complexes potentially suitable for photo-triggered drug release. Work to attach modified water soluble B vitamins such as riboflavin (B2) to the cobalt(III)salen complex is underway. We expect these complexes to be actively transported across the cell membrane into dividing tumor cells. Initial feasibility studies involving modification of riboflavin, attachment to the Co(III) complex, and tagging with a fluorescent reporter group will be discussed.                                                                  

Towards B vitamin targeted light-activated cancer drug conjugates

240th National Meeting (2010)

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