Isolated in 2006 from the Antarctic tunicate Synoicum adareanum, palmerolide A (1) is a unique marine-derived polyketide macrolide with remarkable selectivity towards human melanoma cancer cell lines. This paper will detail recent progress towards 1 utilising a synthetic strategy which relies on the late stage introduction of the enamide side chain, with strategic bond disconnections at C8-C9 and C14-C15 to reveal three key subunits [C1-C8 (2), C9-C14 (3) and C15-C24 (4)]. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/239nm/uploads/9809_deyaaabs.jpg' alt='' />

Studies towards the synthesis of palmerolide A

240th National Meeting (2010)

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